Validation of a quantitation method for conjugated quercetin in human plasma

Yui Sudaka, Takafumi Mitsui, Hiroaki Kida, Mst. Julia Sultana, Miyu Nishikawa, Shinichi Ikushiro and Naoto Yamaguchi

Journal of Pharmaceutical and Biomedical Analysis, 2025, 258, 116738
DOI: 10.1016/j.jpba.2025.116738

Regio-specific synthesis of flavonoid glucuronides using plant UDP-glucuronosyltransferase expressed in yeast

Mst Julia Sultana, Takuto Kurakawa, Miyu Nishikawa and Shinichi Ikushiro

Bioscience, Biotechnology, and Biochemistry, 2025, 89, 954
DOI: 10.1093/bbb/zbaf049

Manipulating flavonoid biosynthesis in Trigonella persica through controlled spectral lighting

Ehsan Bakhshy, Fatemeh Zarinkamar, Bahram Mohammad Soltani and Mehrdad Nazari

Industrial Crops and Products, 2024, 222, 120016
DOI: 10.1016/j.indcrop.2024.120016

Quercetin ameliorates doxorubicin-induced atrial fibrillation via EGFR-mediated restoration of autophagic flux

Wei-Hua Bian, Shi-Hao Wang, Ze-Chun Kang, Yong Xu, Ya-Nuo Li, Mei-Zi Yang, Jun-Hou Yang, Jun-Yao Liu, Yan-Li Cheng, Dong Chang and Xin Xie

Phytomedicine, 2025, 148, 157357
DOI: 10.1016/j.phymed.2025.157357

Insight of traditional Chinese medicine in treating pulmonary hypertension: Achievements from 2021 to 2025

Ruolan Wang, Zhenghua Wang, Yuxin Weng and Shoude Zhang

Journal of Ethnopharmacology, 2026, 364, 121545
DOI: 10.1016/j.jep.2026.121545

Development of a Sequential Fractionation-and-Recovery Method for Multiple Anti-Inflammatory Components Contained in the Dried Red Alga Dulse (Palmaria palmata)

Ga-Hyun Joe, Masafumi Masuoka, Ryosuke Reisen, Seiya Tanaka and Hiroki Saeki

Marine Drugs, 2023, 21, 276
DOI: 10.3390/md21050276

Conjugate Position of Glucuronide and Sulfate in Piceatannol Derivatives Affects the Stability and Hydrolytic Resistance of the Conjugate in Biological Matrices

Miyu Nishikawa, Mai Nakayama, Keisuke Fukaya, Daisuke Urabe and Shinichi Ikushiro

J. Agric. Food Chem., 2025, 73, 495
DOI: 10.1021/acs.jafc.4c08072

Flavonoids in breast milk and their absorption, metabolism, and bioactivity in infants

Akari Ishisaka, Nao Fujiwara, Rie Mukai, Miyu Nishikawa, Shinichi Ikushiro and Akira Murakami

Bioscience, Biotechnology, and Biochemistry, 2025, 89, 165
DOI: 10.1093/bbb/zbae140

Single oral administration of quercetin glycosides prevented acute hyperglycemia by ‍promoting GLUT4 translocation in skeletal muscles through the activation of AMPK in mice

Yoko Yamashita, Hao Jiang, Fukiko Okada, Tomoya Kitakaze, Yasukiyo Yoshioka and Hitoshi Ashida

J. Clin. Biochem. Nutr., 2024, 74, 37
DOI: 10.3164/jcbn.23-30

Placental transfer of quercetin and its metabolites to fetuses in pregnant mice

Nao Fujiwara, Kyoka Matsubara, Rie Mukai, Miyu Nishikawa, Shinichi Ikushiro, Akira Murakami and Akari Ishisaka

Biochemical and Biophysical Research Communications, 2025, 788, 152827
DOI: 10.1016/j.bbrc.2025.152827

Comparison of metabolism and biological properties among positional isomers of quercetin glucuronide in LPS- and RANKL-challenged RAW264.7 cells

Miyu Nishikawa, Yuriko Kada, Mirai Kimata, Toshiyuki Sakaki and Shinichi Ikushiro

Bioscience, Biotechnology, and Biochemistry, 2022, 86, 1670
DOI: 10.1093/bbb/zbac150

A critical examination of human data for the biological activity of quercetin and its phase-2 conjugates

Gary Williamson and Michael N. Clifford

Critical Reviews in Food Science and Nutrition, 2025, 65, 1669
DOI: 10.1080/10408398.2023.2299329

Recombinant Yeast Platform for Production and Verification of Diverse Quercetin Heteroconjugates

Mst. Julia Sultana, Miyu Nishikawa, Yui Sudaka and Shinichi Ikushiro

J. Agric. Food Chem., 2025, 73, 29638
DOI: 10.1021/acs.jafc.5c10497

4″-Sulfation Is the Major Metabolic Pathway of Epigallocatechin-3-gallate in Humans: Characterization of Metabolites, Enzymatic Analysis, and Pharmacokinetic Profiling

Akane Hayashi, Shimpei Terasaka, Yuko Nukada, Akiyo Kameyama, Masayuki Yamane, Ryuta Shioi, Masazumi Iwashita, Kohjiro Hashizume and Osamu Morita

J. Agric. Food Chem., 2022, 70, 8264
DOI: 10.1021/acs.jafc.2c02150

Species-specific deglucuronidation of quercetin glucuronides by the human gut microbiota

Mst Julia Sultana, Yuta Yoshida, Shin Kurihara, Miyu Nishikawa and Shinichi Ikushiro

Bioscience, Biotechnology, and Biochemistry, 2026
DOI: 10.1093/bbb/zbag032

White Wine—Induced Endothelium-Dependent Vasorelaxation in Sprague-Dawley Rats

Zrinka Mihaljević, Toni Kujundžić, Vladimir Jukić, Ana Stupin, Mato Drenjančević and Ines Drenjančević

Antioxidants, 2022, 11, 944
DOI: 10.3390/antiox11050944

Dietary Polyphenols-Gut Microbiota Interactions: Intervention Strategies and Metabolic Regulation for Intestinal Diseases

Huangkun Li, Ji’an Gao, Wenting Peng, Xihan Sun, Wentao Qi and Yong Wang

Biology, 2025, 14, 1705
DOI: 10.3390/biology14121705