Issue 2, 2022

Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients

Abstract

Continuous flow chemistry has opened a new paradigm in both the laboratory and pharmaceutical industry. This review details the recently reported literature on continuous multistep telescoped synthesis of active pharmaceutical ingredients (APIs), inline flow downstream processing, in-process monitoring by process analytical technology (PAT) in flow, flow automation and artificial intelligence (AI) and robotics. We envisage that the integration of all these techniques can ensure an ‘ideal’ smart and efficient 21st century API chemical process that dramatically improves efficiency, agility, quality and flexibility in the manufacturing of pharmaceuticals.

Graphical abstract: Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients

Article information

Article type
Review Article
Submitted
03 nov 2021
Accepted
15 dec 2021
First published
30 dec 2021

React. Chem. Eng., 2022,7, 214-244

Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients

C. R. Sagandira, S. Nqeketo, K. Mhlana, T. Sonti, S. Gaqa and P. Watts, React. Chem. Eng., 2022, 7, 214 DOI: 10.1039/D1RE00483B

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