Issue 4, 2021

Double-acceptor conjugated polymers for NIR-II fluorescence imaging and NIR-II photothermal therapy applications

Abstract

Single-component nanoplatforms combined with the second near-infrared optical window (NIR-II, 1000–1700 nm) fluorescence imaging (FI) and NIR-II photothermal therapy (PTT) have received increasing attention owing to their capacity for precise diagnosis, noninvasive therapy, and real-time monitoring of the therapeutic effects. However, most of the PTT treatments are performed in the NIR-I window (700–900 nm). Moreover, the design and development of conjugated polymers (P1, P2, and P3) with both bright NIR-II fluorescence and superior NIR-II photothermal effect remained a huge challenge. Therefore, three double-acceptor conjugated polymers were designed and developed by adjusting the molar ratios of two acceptors, TTQ and DPP. Subsequently, their corresponding nanoparticles were fabricated, and finally, nanoparticles based on the conjugated polymer P1 (P1 NPs) with both high NIR-II fluorescence intensity and superior NIR-II photothermal efficiency were selected and applied for NIR-II FI and NIR-II PTT. Importantly, the experiments of in vivo NIR-II FI and NIR-II PTT demonstrated that P1 NPs exhibited not only high accumulation in the tumour sites and high sign-to-background ratio (SBR) of vascular imaging, but also superior NIR-II PTT efficiency for tumour treatment.

Graphical abstract: Double-acceptor conjugated polymers for NIR-II fluorescence imaging and NIR-II photothermal therapy applications

Supplementary files

Article information

Article type
Paper
Submitted
22 okt 2020
Accepted
01 dec 2020
First published
09 dec 2020

J. Mater. Chem. B, 2021,9, 1002-1008

Double-acceptor conjugated polymers for NIR-II fluorescence imaging and NIR-II photothermal therapy applications

Y. Chen, B. Sun, X. Jiang, Z. Yuan, S. Chen, P. Sun, Q. Fan and W. Huang, J. Mater. Chem. B, 2021, 9, 1002 DOI: 10.1039/D0TB02499F

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