Issue 43, 2021

Oxidative electro-organic synthesis of dimeric hexahydropyrrolo-[2,3-b]indole alkaloids involving PCET: total synthesis of (±)-folicanthine

Abstract

An efficient electrochemical oxidation strategy for the total synthesis of a dimeric hexahydropyrrolo[2,3-b]indole alkaloid, (±)-folicanthine (1b), has been envisioned. Control experiments suggest that a PCET pathway involving stepwise electron transfer followed by proton transfer (ET-PT) was involved in the key oxidative dimerization process.

Graphical abstract: Oxidative electro-organic synthesis of dimeric hexahydropyrrolo-[2,3-b]indole alkaloids involving PCET: total synthesis of (±)-folicanthine

Supplementary files

Article information

Article type
Communication
Submitted
27 jul 2021
Accepted
02 okt 2021
First published
19 okt 2021

Org. Biomol. Chem., 2021,19, 9390-9395

Oxidative electro-organic synthesis of dimeric hexahydropyrrolo-[2,3-b]indole alkaloids involving PCET: total synthesis of (±)-folicanthine

K. Shaw, S. Sharma, A. Khatua, A. Paul and A. Bisai, Org. Biomol. Chem., 2021, 19, 9390 DOI: 10.1039/D1OB01463C

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