Issue 32, 2021

Biorenewable carbon-supported Ru catalyst for N-alkylation of amines with alcohols and selective hydrogenation of nitroarenes

Abstract

Herein, we developed a renewable carbon-supported Ru catalyst (Ru/PNC-700), which was facilely prepared via simple impregnation followed by the pyrolysis process. The prepared Ru/PNC-700 catalyst demonstrated remarkable catalytic activity in terms of conversion and selectivity towards N-alkylation of anilines with benzyl alcohol and chemoselective hydrogenation of aromatic nitro compounds. In addition, local anesthetic pharmaceutical agents (e.g., butamben and benzocaine), including key drug intermediates, were synthesized in excellent yields under mild conditions and in the presence of water as a green solvent. Moreover, the prepared Ru/PNC-700 catalyst could be easily recovered and reused up to five times without any apparent loss in activity and selectivity.

Graphical abstract: Biorenewable carbon-supported Ru catalyst for N-alkylation of amines with alcohols and selective hydrogenation of nitroarenes

Supplementary files

Article information

Article type
Paper
Submitted
05 apr 2021
Accepted
09 jul 2021
First published
10 jul 2021

New J. Chem., 2021,45, 14687-14694

Biorenewable carbon-supported Ru catalyst for N-alkylation of amines with alcohols and selective hydrogenation of nitroarenes

V. Goyal, N. Sarki, M. K. Poddar, A. Narani, D. Tripathi, A. Ray and K. Natte, New J. Chem., 2021, 45, 14687 DOI: 10.1039/D1NJ01654G

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