Issue 27, 2016

Structural features and molecular aggregations of designed triple-stranded β-sheets in single crystals

Abstract

Design, synthesis and single-crystal conformations of hybrid triple-stranded β-sheets composed of E-vinylogous residues are reported. Restricting conformational flexibility of β-strands through the insertion of carbon–carbon double bonds at facing positions leads to increased peptide crystallinity, which allowed unambiguous structural characterization of three-stranded β-sheets. This strategy can be further explored for the design of functional β-sheets.

Graphical abstract: Structural features and molecular aggregations of designed triple-stranded β-sheets in single crystals

  • This article is part of the themed collection: Foldamers

Supplementary files

Article information

Article type
Communication
Submitted
06 jan 2016
Accepted
04 mar 2016
First published
04 mar 2016

Chem. Commun., 2016,52, 4938-4941

Structural features and molecular aggregations of designed triple-stranded β-sheets in single crystals

A. Bandyopadhyay, R. Misra and H. N. Gopi, Chem. Commun., 2016, 52, 4938 DOI: 10.1039/C6CC00127K

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