Issue 3, 2015

The English (H6R) familial Alzheimer's disease mutation facilitates zinc-induced dimerization of the amyloid-β metal-binding domain

Abstract

Interaction of Zn2+ with the metal-binding domain of the English (H6R) amyloid-β mutant results in the formation of peptide dimers. The mutation causes the exclusion of His6 from the zinc chelation pattern observed in the intact domain and triggers the assembly of the dimers via zinc ions coordinated by 11EVHH14 fragments.

Graphical abstract: The English (H6R) familial Alzheimer's disease mutation facilitates zinc-induced dimerization of the amyloid-β metal-binding domain

Supplementary files

Article information

Article type
Communication
Submitted
01 okt 2014
Accepted
13 feb 2015
First published
13 feb 2015

Metallomics, 2015,7, 422-425

Author version available

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