Issue 33, 2011
From the journal:

Chemical Communications

Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells†‡

Mihai Ciobanu,a   Kuo-Ting Huang,a   Jean-Pierre Daguer,a   Sofia Barluenga,a   Olivier Chaloin,b   Evelyne Schaeffer,b   Christopher G. Mueller,b   Daniel A. Mitchellc  and  Nicolas Winssinger*a  

* Corresponding authors

a Institut de Science et Ingenierie Supramoleculaires (ISIS), Université de Strasbourg—CNRS, 8 allee Gaspard Monge, 67000 Strasbourg, France
E-mail: winssinger@isis.u-strasbg.fr

b Institut de Biologie Moleculaire et Cellulaire Université de Strasbourg—CNRS (UPR9021), Strasbourg, France

c Warwick Medical School, University of Warwick, UK

Abstract

We report the synthesis of a nucleic acid-encoded carbohydrate library, its combinatorial self-assembly into 37 485 pairs and a screen against DC-SIGN leading to the identification of consensus ligand motifs. A prototypical example from the selected pairs was shown to have enhanced binding. A dendrimer incorporating the selected motifs inhibited gp120's binding to dendritic cells with higher efficiency than mannan.

Graphical abstract: Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells

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Article information

DOI
https://doi.org/10.1039/C1CC13213J
Article type
Communication
Submitted
31 maj 2011
Accepted
30 jun 2011
First published
25 jul 2011

Chem. Commun., 2011,47, 9321-9323

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Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells

M. Ciobanu, K. Huang, J. Daguer, S. Barluenga, O. Chaloin, E. Schaeffer, C. G. Mueller, D. A. Mitchell and N. Winssinger, Chem. Commun., 2011, 47, 9321 DOI: 10.1039/C1CC13213J

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