Volume 241, 2023

Application of resonant acoustic mixing in the synthesis of vitamin C–nicotinamide variable stoichiometry cocrystals

Abstract

The use of resonant acoustic mixing (RAM) to synthesize variable stoichiometry cocrystals of nicotinamide and vitamin C was investigated. Liquid assisted RAM (LA-RAM) was used to generate two polymorphs, Form I and II, of the 1 : 1 cocrystal of nicotinamide and vitamin C at a 700 mg scale using ethanol and methanol respectively as the liquid additives. LA-RAM was used to scale up polymorphs I and II of the 1 : 1 cocrystal to 20 grams. Finally, LA-RAM used was to produce a high purity 3 : 1 cocrystal of nicotinamide and vitamin C when either methanol or ethanol was used as the liquid additive. LA-RAM is demonstrated to be a scalable, environmentally friendly, ball-free method to make variable stoichiometry cocrystals.

Graphical abstract: Application of resonant acoustic mixing in the synthesis of vitamin C–nicotinamide variable stoichiometry cocrystals

Associated articles

Supplementary files

Article information

Article type
Paper
Submitted
04 jun 2022
Accepted
25 jul 2022
First published
25 jul 2022

Faraday Discuss., 2023,241, 357-366

Application of resonant acoustic mixing in the synthesis of vitamin C–nicotinamide variable stoichiometry cocrystals

M. Bui, P. Chakravarty and K. Nagapudi, Faraday Discuss., 2023, 241, 357 DOI: 10.1039/D2FD00124A

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