Issue 5, 2022

Coordination-assisted, transition-metal-catalyzed enantioselective desymmetric C–H functionalization

Abstract

Transition-metal-catalyzed asymmetric C–H functionalization has gradually emerged as a powerful tool for the creation of structural and chiral complexity in an atom- and step-economical fashion. The nature of this strategy provides a variety of methodologies to overcome the limitation of enantioselective desymmetrization caused by the synthesis of preformed multifunctional symmetric substrates. This review aims to summarise recent advances in transition-metal-catalyzed enantioselective desymmetric C–H functionalization reactions via coordination-assisted metal insertion, covering the literature from 2008 to June 2021. The mechanistic pathway and the modes of stereocontrol are discussed where appropriate.

Graphical abstract: Coordination-assisted, transition-metal-catalyzed enantioselective desymmetric C–H functionalization

Article information

Article type
Review Article
Submitted
18 dec 2021
Accepted
06 jan 2022
First published
07 jan 2022

Org. Chem. Front., 2022,9, 1458-1484

Coordination-assisted, transition-metal-catalyzed enantioselective desymmetric C–H functionalization

X. Yu, Z. Zhang, J. Niu and B. Shi, Org. Chem. Front., 2022, 9, 1458 DOI: 10.1039/D1QO01884A

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