Issue 11, 2022

Recent progress in rare-earth metal-catalyzed sp2 and sp3 C–H functionalization to construct C–C and C–heteroelement bonds

Abstract

C–H functionalization is a fundamentally important organic transformation to access C–C and C–heteroatom bonds in a common and/or complex molecular set-up during the preparation of small molecule bio-active scaffolds and conglomerate molecular architectures, generating valuable structural diversity. C–H activation/functionalization has become routine in the toolbox of synthetic organic, medicinal and materials chemists. In the last few years, half-sandwich rare-earth metal-catalyzed C–C and C–heteroatom bond formation has gained significant momentum, which is enabled by C–H activation/functionalization in a highly site-/regio-, and enantio-/diastereo-selective manner. This account is focused on presenting an overview of the recent studies on different types of rare-earth metal-catalyzed organic transformations, such as C–C/C–heteroatom bond formation and olefin (co)-polymerization. Also, we discuss sp2 and sp3 C–H functionalization under the catalytic influence of rare-earth metal-elements, covering reports from 2010 to March 2021. Mechanistic considerations are covered briefly, wherein significant understanding was realized by both experimental studies and density functional theory calculations.

Graphical abstract: Recent progress in rare-earth metal-catalyzed sp2 and sp3 C–H functionalization to construct C–C and C–heteroelement bonds

Article information

Article type
Review Article
Submitted
15 dec 2021
Accepted
14 apr 2022
First published
15 apr 2022

Org. Chem. Front., 2022,9, 3102-3141

Recent progress in rare-earth metal-catalyzed sp2 and sp3 C–H functionalization to construct C–C and C–heteroelement bonds

K. Seth, Org. Chem. Front., 2022, 9, 3102 DOI: 10.1039/D1QO01859K

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