Issue 73, 2022

Highly sensitive acetylcholine biosensing via chemical amplification of enzymatic processes in nanochannels

Abstract

Acetylcholinesterase-modified nanochannels are proposed as reliable and reproducible nanofluidic sensors for highly sensitive detection of acetylcholine. The operation mechanism relies on the use of weak polyelectrolytes as “chemical amplifiers” that adjust/reconfigure the nanochannel surface charge in the presence of local pH changes induced by the enzymatic reaction. Experimental results show that the presence of acetylcholine can be transduced into measurable ionic signals with a low limit of detection.

Graphical abstract: Highly sensitive acetylcholine biosensing via chemical amplification of enzymatic processes in nanochannels

Supplementary files

Article information

Article type
Communication
Submitted
21 apr 2022
Accepted
11 avg 2022
First published
11 avg 2022

Chem. Commun., 2022,58, 10166-10169

Highly sensitive acetylcholine biosensing via chemical amplification of enzymatic processes in nanochannels

Y. Toum Terrones, G. Laucirica, V. M. Cayón, G. E. Fenoy, M. L. Cortez, M. E. Toimil-Molares, C. Trautmann, W. A. Mamisollé and O. Azzaroni, Chem. Commun., 2022, 58, 10166 DOI: 10.1039/D2CC02249D

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