Issue 23, 2021

Alkoxycarbonyl radicals from alkyloxalyl chlorides: photoinduced synthesis of isoquinolinediones under visible light irradiation

Abstract

Alkyloxalyl chlorides, generated from alcohols and oxalyl chlorides, are used as alkoxycarbonyl radicals in the reaction of N-acryloyl benzamides under photocatalysis at room temperature. In this report, we demonstrate that this approach can be compatible with a variety of alcohol-containing pharmaceutically active compounds under visible light irradiation. A variety of isoquinoline-1,3(2H,4H)-diones are prepared in moderate to good yields.

Graphical abstract: Alkoxycarbonyl radicals from alkyloxalyl chlorides: photoinduced synthesis of isoquinolinediones under visible light irradiation

Supplementary files

Article information

Article type
Research Article
Submitted
13 sep 2021
Accepted
20 okt 2021
First published
22 okt 2021

Org. Chem. Front., 2021,8, 6704-6709

Alkoxycarbonyl radicals from alkyloxalyl chlorides: photoinduced synthesis of isoquinolinediones under visible light irradiation

M. Ji, L. Xu, X. Luo, M. Jiang, S. Wang, J. Chen and J. Wu, Org. Chem. Front., 2021, 8, 6704 DOI: 10.1039/D1QO01368H

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