Issue 5, 2021

Copper-catalyzed three-component oxycyanation of alkenes

Abstract

A copper-catalyzed, three-component reaction for the direct oxycyanation of various alkenes with aryl diacyl peroxides and trimethylsilyl cyanide has been developed. Both unactivated alkenes and styrenes are reliable substrates and produce β-cyanohydrin derivatives. An asymmetric version of this reaction has been conducted and proceeds well.

Graphical abstract: Copper-catalyzed three-component oxycyanation of alkenes

Supplementary files

Article information

Article type
Research Article
Submitted
18 nov 2020
Accepted
22 dec 2020
First published
25 dec 2020

Org. Chem. Front., 2021,8, 908-914

Copper-catalyzed three-component oxycyanation of alkenes

Y. Zeng, Y. Li, D. Lv and H. Bao, Org. Chem. Front., 2021, 8, 908 DOI: 10.1039/D0QO01437K

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