Issue 12, 2021

Innovative strategies of hydrogen peroxide-involving tumor therapeutics

Abstract

Hydrogen peroxide (H2O2) with a high level in solid tumor microenvironments has been widely investigated as an important target in the design and application of various novel anticancer strategies. Among these strategies, H2O2 can be used as an oxygen supplier to improve the therapeutic effects of hypoxia-limited treatment modes including chemotherapy (CT), radiotherapy (RT), photodynamic therapy (PDT), sonodynamic therapy (SDT), and starvation therapy (ST). Moreover, it can participate in Fenton or Fenton-like reactions to produce ˙OH with increased toxicity for chemodynamic therapy (CDT). H2O2-involving CDT can also be combined with other anticancer therapies, such as CT, RT, PDT, SDT, photothermal therapy, and ST, to achieve better anticancer effects than the single treatment mode. In this review, various recently reported anticancer treatments involving H2O2 were summarized. Future prospects inspired by these excellent studies were also discussed to promote the development of the anticancer field involving H2O2.

Graphical abstract: Innovative strategies of hydrogen peroxide-involving tumor therapeutics

Article information

Article type
Review Article
Submitted
26 jan 2021
Accepted
09 mar 2021
First published
18 mar 2021

Mater. Chem. Front., 2021,5, 4474-4501

Innovative strategies of hydrogen peroxide-involving tumor therapeutics

Y. Zhang, J. Zhang, Q. Jia, J. Ge and P. Wang, Mater. Chem. Front., 2021, 5, 4474 DOI: 10.1039/D1QM00134E

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