Advances in biomedical applications of self-healing hydrogels

Hassan Rammal; Amin GhavamiNejad; Ahmet Erdem; Rene Mbeleck; Mohammad Nematollahi; Sibel Emir Diltemiz; Halima Alem; Mohammad Ali Darabi; Yavuz Nuri Ertas; Edward J. Caterson; Nureddin Ashammakhi

doi:10.1039/D0QM01099E

Advances in biomedical applications of self-healing hydrogels

Hassan Rammal,

†^ab Amin GhavamiNejad,

†^c Ahmet Erdem,^de Rene Mbeleck,^f Mohammad Nematollahi,

^g Sibel Emir Diltemiz,^h Halima Alem,ⁱ Mohammad Ali Darabi,^j Yavuz Nuri Ertas,^kl Edward J. Caterson^m and Nureddin Ashammakhi

*^no

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^a Equipe de Recherche sur les Relations Matrice Extracellulaire-Cellules (ERRMECe), Biomaterials for Health Research Group, Institut des Matériaux, Maison International de la Recherche, Université de Cergy-Pontoise, 95000 Neuville sur Oise, France

^b EFOR Healthcare Paris, Biocompatibility Platform, Levallois-Perret, France

^c Advanced Pharmaceutics and Drug Delivery Laboratory, Leslie L. Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada

^d Department of Chemistry, Kocaeli University, Umuttepe Campus, Kocaeli, Turkey

^e Department of Biomedical Engineering, Kocaeli University, Umuttepe Campus, Turkey

^f Faculty of Engineering, University of Manitoba, Winnipeg, Canada

^g Department of Mechanical Engineering, University of Manitoba, 75A Chancellors Circle, Winnipeg, Manitoba R3T 5V6, Canada

^h Department of Chemistry, Eskisehir Technical University, Eskisehir, Turkey

ⁱ Université de Lorraine, CNRS, IJL, F-54000 Nancy, France

^j Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, California, USA

^k Department of Biomedical Engineering, Erciyes University, Kayseri, Turkey

^l ERNAM – Nanotechnology Research and Application Center, Erciyes University, Kayseri, Turkey

^m Division of plastic surgery, department of surgery Nemours/Alfred I. du Pont Hospital for Children, Wilmington, DE, USA

ⁿ Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, CA 90095, USA
E-mail: n.ashammakhi@ucla.edu

^o Department of Biomedical Engineering, Michigan State University, East Lansing, MI 48824, USA

Abstract

Hydrogels are important biomaterials that have several applications in drug and cell delivery, tissue engineering, three-dimensional (3D) printing and more recently, in sensing and actuating applications. With the advent of self-healing hydrogels, it is becoming possible to have smarter materials with sustainable mechanical properties under stress and also added functionalities. The mechanisms responsible for the self-healing behavior of these materials are related to their internal structure and processes triggered by damage they may sustain. These mechanisms rely on either chemical bonding or physical interactions of the structural components of hydrogels, or on both. Many self-healing hydrogels have been developed and tested in vitro and in animals. However, there are still challenges, especially with healing characteristics that need to be addressed and investigated in animal experiments before their clinical applications can be initiated, for which a multidisciplinary approach is required. In the current paper, various biomedical applications of self-healing hydrogels are discussed in detail, highlighting current challenges and future prospects.

This article is part of the themed collection: 2021 Materials Chemistry Frontiers Review-type Articles

Materials Chemistry Frontiers

Advances in biomedical applications of self-healing hydrogels

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