Issue 1, 2021

Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly

Abstract

Core–shell nanoparticles (NPs) with a boron-rich core were synthesized by RAFT-mediated polymerization-induced self-assembly using a new methacrylic boronate ester monomer. Under specific conditions, sub-100 nm spherical NPs could be obtained at high conversions by either emulsion or dispersion RAFT polymerization using poly(oligo(ethylene glycol) methacrylate) (POEGMA) dithiobenozate-based chain transfer agents. Phenylboronic acid surface-functionalized NPs were obtained using a telechelic POEGMA. Primary data on biocompatibility is provided and suggests suitability as boron delivery agent for boron neutron capture therapy.

Graphical abstract: Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly

Supplementary files

Article information

Article type
Communication
Submitted
15 maj 2020
Accepted
29 jul 2020
First published
05 avg 2020
This article is Open Access
Creative Commons BY license

Polym. Chem., 2021,12, 50-56

Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly

L. S. Huang, D. Le, I. Hsiao, S. Fritsch-Decker, C. Hald, S. Huang, J. Chen, J. R. Hwu, C. Weiss, M. Hsu and G. Delaittre, Polym. Chem., 2021, 12, 50 DOI: 10.1039/D0PY00710B

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