Issue 37, 2021

Thermally induced silane dehydrocoupling on porous silicon nanoparticles for ultra-long-acting drug release

Abstract

Here, we report an ultra-long-acting drug release nano-formulation based on porous silicon nanoparticles (pSiNPs) that are prepared by thermally induced silane dehydrocoupling and lipid-coating. This robust formulation offers the ability to release an anticancer drug, for up to 2 weeks, in various biological environments; pH 7.4 buffer, cancer cells, and tumor xenograft model.

Graphical abstract: Thermally induced silane dehydrocoupling on porous silicon nanoparticles for ultra-long-acting drug release

Supplementary files

Article information

Article type
Communication
Submitted
21 maj 2021
Accepted
04 avg 2021
First published
20 avg 2021

Nanoscale, 2021,13, 15560-15568

Thermally induced silane dehydrocoupling on porous silicon nanoparticles for ultra-long-acting drug release

J. H. Oh, R. H. Kang, J. Kim, E. Bang and D. Kim, Nanoscale, 2021, 13, 15560 DOI: 10.1039/D1NR03263A

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