Issue 10, 2021

Lanthanide upconversion and downshifting luminescence for biomolecules detection

Abstract

Biomolecules play critical roles in biological activities and are closely related to various disease conditions. The reliable, selective and sensitive detection of biomolecules holds much promise for specific and rapid biosensing. In recent years, luminescent lanthanide probes have been widely used for monitoring the activity of biomolecules owing to their long luminescence lifetimes and line-like emission which allow time-resolved and ratiometric analyses. In this review article, we concentrate on recent advances in the detection of biomolecule activities based on lanthanide luminescent systems, including upconversion luminescent nanoparticles, lanthanide–metal organic frameworks, and lanthanide organic complexes. We also introduce the latest remarkable accomplishments of lanthanide probes in the design principles and sensing mechanisms, as well as the forthcoming challenges and perspectives for practical achievements.

Graphical abstract: Lanthanide upconversion and downshifting luminescence for biomolecules detection

Article information

Article type
Review Article
Submitted
31 maj 2021
Accepted
29 jul 2021
First published
29 jul 2021

Nanoscale Horiz., 2021,6, 766-780

Lanthanide upconversion and downshifting luminescence for biomolecules detection

G. Sun, Y. Xie, L. Sun and H. Zhang, Nanoscale Horiz., 2021, 6, 766 DOI: 10.1039/D1NH00299F

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