Issue 6, 2020

ATP-fuelled self-assembly to regulate chemical reactivity in the time domain

Abstract

Here, we exploit a small biomolecule – ATP – to gain temporal control over chemical reactivity in a synthetic system composed of small self-assembling molecules and reactants. The approach relies on the capacity of ATP to template the formation of amphiphile-based assemblies. The presence of the enzyme alkaline phosphatase causes a gradual decrease in the ATP-concentration in time and, consequently, a spontaneous dissociation of the assemblies. The uptake of apolar reactants in the hydrophobic domain of the assemblies leads to an enhancement of the reaction rate. It is shown that ATP-triggered self-assembly causes the selective upregulation of one out of two hydrazone-bond formation reactions that take place concurrently in the system. This leads to an inversion in the product ratio, which, however, is transient in nature because the upregulated reaction spontaneously reverts to its basal low reaction rate once the ATP has been consumed by the enzyme. Overall, the results demonstrate the potential of chemically-fuelled self-assembly under dissipative conditions to gain temporal control over reactivity in complex chemical systems.

Graphical abstract: ATP-fuelled self-assembly to regulate chemical reactivity in the time domain

Supplementary files

Article information

Article type
Edge Article
Submitted
14 okt 2019
Accepted
17 dec 2019
First published
18 dec 2019
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2020,11, 1518-1522

ATP-fuelled self-assembly to regulate chemical reactivity in the time domain

M. A. Cardona and L. J. Prins, Chem. Sci., 2020, 11, 1518 DOI: 10.1039/C9SC05188K

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