Issue 23, 2020

Progresses in organocatalytic asymmetric dearomatization reactions of indole derivatives

Abstract

Chiral indole derivatives such as indolines and indolenines are important heterocyclic frameworks which constitute the core structures of many natural products and bioactive molecules. So, intensive attentions from chemists have been paid to the construction of such frameworks. Among different approaches, organocatalytic asymmetric dearomatization (organo-CADA) reactions of indole derivatives have become powerful methods toward this goal. Consequently, a variety of enantioenriched heterocyclic frameworks containing indoline, indolenine and the related cores have been constructed via organo-CADA reactions of indole derivatives, and a series of important natural products with structural complexity and enantiopurity have been synthesized based on these methodologies. This review summarizes the progresses in organo-CADA reactions of indole derivatives since 2004 and their applications in total synthesis of natural products, and gives some insights into challenging issues in this research field, which will enlighten the future development of this field.

Graphical abstract: Progresses in organocatalytic asymmetric dearomatization reactions of indole derivatives

Article information

Article type
Review Article
Submitted
15 sep 2020
Accepted
13 okt 2020
First published
13 okt 2020

Org. Chem. Front., 2020,7, 3967-3998

Progresses in organocatalytic asymmetric dearomatization reactions of indole derivatives

F. Sheng, J. Wang, W. Tan, Y. Zhang and F. Shi, Org. Chem. Front., 2020, 7, 3967 DOI: 10.1039/D0QO01124J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements