Issue 23, 2020

Ni-Catalyzed stereoselective difunctionalization of alkynes

Abstract

Tri- and tetrasubstituted olefins are widely present in biologically active molecules and functional materials. However, the methods for the stereoselective construction of such moieties are still very limited and extremely challenging. The transition-metal-catalyzed difunctionalization of alkynes is one of the most straightforward and effective choices. In this review, we summarize the progress of the nickel-catalyzed alkyne difunctionalization reaction, with an emphasis on the strategy and control of stereochemistry.

Graphical abstract: Ni-Catalyzed stereoselective difunctionalization of alkynes

Article information

Article type
Review Article
Submitted
09 sep 2020
Accepted
13 okt 2020
First published
13 okt 2020

Org. Chem. Front., 2020,7, 3941-3955

Ni-Catalyzed stereoselective difunctionalization of alkynes

W. Liu and W. Kong, Org. Chem. Front., 2020, 7, 3941 DOI: 10.1039/D0QO01097A

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