Issue 5, 2020

Chemically modified nucleic acid biopolymers used in biosensing

Abstract

Biopolymers are highly designable and are often used in biosensing processes. As a biopolymer, a nucleic acid not only has excellent programmability and biocompatibility, but also has a certain molecular recognition function that can directly realize biological recognition in biosensors. However, the structural variety of natural nucleotides hinders the designability of nucleic acid biopolymers. The introduction of chemical modifications in nucleic acids can enrich the designability of nucleic acid biopolymers, thereby expanding their applications in biosensing. To date, there have been many reviews paying attention to biopolymers used in biosensing, but few reviews have focused on chemically modified nucleic acid biopolymers. Here, we review different kinds of assemblies based on chemically modified nucleic acid biopolymers. We summarize their advances in the field of biosensing. Furthermore, we present challenges and prospects in this field, aiming to provide a promising step for a versatile biosensor platform based on chemically modified nucleic acid biopolymers.

Graphical abstract: Chemically modified nucleic acid biopolymers used in biosensing

Article information

Article type
Review Article
Submitted
15 jan 2020
Accepted
14 feb 2020
First published
18 feb 2020

Mater. Chem. Front., 2020,4, 1315-1327

Chemically modified nucleic acid biopolymers used in biosensing

L. Zhang, Y. Yang, J. Tan and Q. Yuan, Mater. Chem. Front., 2020, 4, 1315 DOI: 10.1039/D0QM00026D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements