Issue 4, 2020

High-order structures from nucleic acids for biomedical applications

Abstract

Over the past 40 years, research in the fields of DNA nanotechnology and RNA nanotechnology has taken nucleic acid molecules out of their biological contexts and harnessed their unique base-pairing and self-assembly properties to generate well-defined, organized, and functional supramolecular architectures. Capitalizing on an intrinsic biocompatibility and the ability to tailor size, shape, and functionality from the bottom up, recent work has positioned high-order nucleic acid structures as powerful biomedical tools. This review summarizes advances in nanotechnology that have enabled the fabrication of synthetic nucleic acid structures. Nucleic acid-based platforms for biosensing and therapeutic drug delivery are highlighted. Finally, an outlook that considers the limitations and future challenges for this field is presented.

Graphical abstract: High-order structures from nucleic acids for biomedical applications

Article information

Article type
Review Article
Submitted
14 okt 2019
Accepted
23 jan 2020
First published
06 feb 2020
This article is Open Access
Creative Commons BY-NC license

Mater. Chem. Front., 2020,4, 1074-1088

High-order structures from nucleic acids for biomedical applications

A. C. Hill and J. Hall, Mater. Chem. Front., 2020, 4, 1074 DOI: 10.1039/C9QM00638A

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