Issue 16, 2019

nBuLi-promoted anti-Markovnikov selective hydroboration of unactivated alkenes and internal alkynes

Abstract

An efficient and general nBuLi-promoted anti-Markovnikov selective hydroboration of various α-alkenes, 1,1-disubstituted alkenes and internal alkynes with pinacolborane for the synthesis of alkylboronic esters is described. This protocol features easy accessibility of catalysts and substrates, a broad substrate scope, and simple operation as well as scale-up ability.

Graphical abstract: n BuLi-promoted anti-Markovnikov selective hydroboration of unactivated alkenes and internal alkynes

Supplementary files

Article information

Article type
Research Article
Submitted
10 jun 2019
Accepted
28 jun 2019
First published
02 jul 2019

Org. Chem. Front., 2019,6, 2949-2953

n BuLi-promoted anti-Markovnikov selective hydroboration of unactivated alkenes and internal alkynes

Z. Wang, M. Wang, J. Gao, S. Shi and Y. Xu, Org. Chem. Front., 2019, 6, 2949 DOI: 10.1039/C9QO00750D

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