Issue 48, 2018

Small molecule generators of biologically reactive sulfur species

Abstract

Sulfur metabolism is integral to cellular growth and survival. The presence of a wide range of oxidation states of sulfur in biology coupled with its unique reactivity are some key features of the biology of this element. In particular, nearly all oxidation states of sulfur not only occur but are also inter-convertible. In order to study the chemical biology of reactive sulfur species, tools to reliably detect as well as generate these species within cells are necessary. Herein, an overview of strategies to generate certain reactive sulfur species is presented. The donors of reactive sulfur species have been organized based on their oxidation states. These interesting small molecules have helped lay a strong foundation to study the biology of reactive sulfur species and some may have therapeutic applications in the future as well.

Graphical abstract: Small molecule generators of biologically reactive sulfur species

Article information

Article type
Review Article
Submitted
28 apr 2018
Accepted
19 jul 2018
First published
31 jul 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 27359-27374

Small molecule generators of biologically reactive sulfur species

P. Bora, P. Chauhan, K. A. Pardeshi and H. Chakrapani, RSC Adv., 2018, 8, 27359 DOI: 10.1039/C8RA03658F

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