Issue 3, 2018

Formation of tetrasubstituted C–C double bonds via olefin metathesis: challenges, catalysts, and applications in natural product synthesis

Abstract

Among the many types of transition-metal-catalysed C–C bond forming reactions, olefin metathesis is without a doubt one of the most thriving fields in modern organic synthetic chemistry. This is due to a wide range of transformations that are possible by olefin metathesis with commercially available and user friendly catalysts. Until recently, the formation of tetrasubstituted double bonds via olefin metathesis is considered as a very challenging topic. Although much attention has already been given in the last two decades to improve this transformation by the modification of catalysts, optimising the conditions, substrate modification and so on, however, none are universally attractive so far. So the field is still quite open and looking for a simple and general solution that suits all challenging substrates. In this context, this review is an attempt to provide a broad but digestible overview of tetrasubstituted C–C double bond formation via olefin metathesis, with an emphasis on the recent developments achieved in this area. These developments are actually signifying the great potential for further advancement of this exhilarating research field.

Graphical abstract: Formation of tetrasubstituted C–C double bonds via olefin metathesis: challenges, catalysts, and applications in natural product synthesis

Article information

Article type
Review Article
Submitted
05 sep 2017
Accepted
03 nov 2017
First published
06 nov 2017

Org. Chem. Front., 2018,5, 494-516

Formation of tetrasubstituted C–C double bonds via olefin metathesis: challenges, catalysts, and applications in natural product synthesis

N. Mukherjee, S. Planer and K. Grela, Org. Chem. Front., 2018, 5, 494 DOI: 10.1039/C7QO00800G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements