Issue 20, 2017

Copper-catalyzed oxidative decarboxylative coupling of α-keto acids and sulfoximines

Abstract

A copper-catalyzed oxidative decarboxylative coupling of α-keto acids with NH-sulfoximines has been developed. With CuBr as the catalyst and K2S2O8 as the oxidant, this reaction enables the formation of a C–N bond and gives N-aroylsulfoximine products in moderate to excellent yields. The reaction mechanism is likely to involve the generation of a reactive aroyl radical intermediate.

Graphical abstract: Copper-catalyzed oxidative decarboxylative coupling of α-keto acids and sulfoximines

Supplementary files

Article information

Article type
Paper
Submitted
29 mar 2017
Accepted
25 apr 2017
First published
26 apr 2017

Org. Biomol. Chem., 2017,15, 4320-4327

Copper-catalyzed oxidative decarboxylative coupling of α-keto acids and sulfoximines

C. Pimpasri, L. Sumunnee and S. Yotphan, Org. Biomol. Chem., 2017, 15, 4320 DOI: 10.1039/C7OB00776K

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