Issue 14, 2017

A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging

Abstract

Aggregation, red-NIR emission and light-up upon nucleic acid G-quadruplex binding have been investigated for a prototype core-extended naphthalene diimide, which is capable of fast cellular entry and nucleolar localization. Both high-level colocalization with an anti-G-quadruplex antibody and nucleolin displacement reveal that the compound targets and thus makes visible nuclear DNA G-quadruplexes.

Graphical abstract: A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging

Supplementary files

Article information

Article type
Communication
Submitted
21 okt 2016
Accepted
23 jan 2017
First published
23 jan 2017
This article is Open Access
Creative Commons BY license

Chem. Commun., 2017,53, 2268-2271

A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging

F. Doria, M. Nadai, M. Zuffo, R. Perrone, M. Freccero and S. N. Richter, Chem. Commun., 2017, 53, 2268 DOI: 10.1039/C6CC08492C

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