Issue 92, 2016

Cu-catalyzed β-functionalization of saturated ketones with indoles: a one-step synthesis of C3-substituted indoles

Abstract

An effective one-pot synthesis of β-indolylketones from saturated ketones and indoles was developed. It is noteworthy that this methodology has a good functional group tolerance (alkyl, nitro, halogen, hydroxyl, methoxyl, carboxyl and ester) and is of great significance to the preparation of many indole heterocycles.

Graphical abstract: Cu-catalyzed β-functionalization of saturated ketones with indoles: a one-step synthesis of C3-substituted indoles

Supplementary files

Article information

Article type
Communication
Submitted
27 jul 2016
Accepted
11 sep 2016
First published
13 sep 2016

RSC Adv., 2016,6, 89181-89184

Cu-catalyzed β-functionalization of saturated ketones with indoles: a one-step synthesis of C3-substituted indoles

Z. Yang, C. Liu, Y. Zeng, J. Zhang, Z. Wang, Z. Fang and K. Guo, RSC Adv., 2016, 6, 89181 DOI: 10.1039/C6RA19000F

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