Issue 94, 2016

Multifunctional mesoporous silica nanocarriers for stimuli-responsive target delivery of anticancer drugs

Abstract

With the rapid development of nanotechnology, mesoporous silica nanoparticles (MSNs), as a new type of inorganic nanomaterial, have been widely used in biomedical applications especially in drug delivery systems owing to their unique physical–chemical properties such as tunable particle/pore size, high surface area and pore volume, easy surface modification, remarkable stability and biocompatibility, and high drug loading efficiency. By modifying the outer surface of MSNs with various functional groups such as polymers, co-polymers, nanoparticles, quantum dots, supermolecules, ligands, or/and using a combination with other nanomaterials, stimuli-responsive and active targeting nanosystems can be designed for targeted delivery of anticancer drugs. In this review, the recent advances in stimuli-responsive strategies involving pH-sensitive, redox-sensitive, thermo-sensitive, enzyme-sensitive, light-sensitive, magnetic-sensitive, ultrasound-sensitive, and active targeting approaches involving vascular targeting, tumor cell targeting, nuclear targeting and multistage targeting are discussed in detail. The remaining challenges and the possible future directions are also suggested.

Graphical abstract: Multifunctional mesoporous silica nanocarriers for stimuli-responsive target delivery of anticancer drugs

Article information

Article type
Review Article
Submitted
15 jul 2016
Accepted
12 sep 2016
First published
20 sep 2016

RSC Adv., 2016,6, 92073-92091

Multifunctional mesoporous silica nanocarriers for stimuli-responsive target delivery of anticancer drugs

Y. Chen, H. Zhang, X. Cai, J. Ji, S. He and G. Zhai, RSC Adv., 2016, 6, 92073 DOI: 10.1039/C6RA18062K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements