Issue 44, 2016

Cu(i)-catalyzed double C–H amination: synthesis of 2-iodo-imidazo[1,2-a]pyridines

Abstract

An iodine/CuI mediated double oxidative C–H amination reaction has been developed for the synthesis of 2-iodo-imidazo[1,2-a]pyridines. The salient features of this methodology are mild reaction conditions and high regioselectivity. The designed compounds e.g. 2-iodo-imidazo[1,2-a]pyridines (3e) may serve as active pharmaceutical ingredients (APIs) of marketed drugs like saripidem and nicopidem. Further saripidem was synthesised by using 3e as an intermediate.

Graphical abstract: Cu(i)-catalyzed double C–H amination: synthesis of 2-iodo-imidazo[1,2-a]pyridines

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
01 feb 2016
Accepted
07 apr 2016
First published
08 apr 2016

RSC Adv., 2016,6, 38033-38036

Cu(I)-catalyzed double C–H amination: synthesis of 2-iodo-imidazo[1,2-a]pyridines

D. Dheer, K. R. Reddy, S. K. Rath, P. L. Sangwan, P. Das and R. Shankar, RSC Adv., 2016, 6, 38033 DOI: 10.1039/C6RA02953A

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