Issue 9, 2016

Interfacing monolith-based electrochromatography in microchips with inductively coupled plasma mass spectrometry for elemental speciation

Abstract

The feasibility of microchip-based electrochromatography interfaced with ICP-MS (μ-EC-ICP-MS) for elemental speciation was first reported, which was achieved by using a homemade nanoflow nebulizer and heated single pass spray chamber. A polymer monolith (poly(butyl methacrylate) (BMA)-co-ethylene dimethacrylate (EDMA)-co-2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS)) was fabricated in a 50 mm microchannel by UV-initiated polymerization. The monolith not only eliminated the laminar flow induced by the nebulizer suction but also ensured variable-volume electrokinetic injection. Factors affecting the EOF rate such as the AMPS percentage and electrochromatographic conditions were optimized. The μ-EC-ICP-MS system offered satisfactory resolutions and reproducibilities (<4.4%) by individually using multiple metallic cations and iodine anions as the models. Detection limits of 0.036–0.075 μg L−1 for mercuric and methylmercuric ions and 0.15–0.22 μg L−1 for arsenite, arsenate, monomethylarsenate and dimethylarsenate were obtained. Mercury speciation in certified fish tissue and arsenic speciation in reference human urine by using the proposed μ-EC-ICP-MS system proved its good applicability in elemental speciation.

Graphical abstract: Interfacing monolith-based electrochromatography in microchips with inductively coupled plasma mass spectrometry for elemental speciation

Supplementary files

Article information

Article type
Paper
Submitted
21 mar 2016
Accepted
28 apr 2016
First published
28 apr 2016

J. Anal. At. Spectrom., 2016,31, 1869-1876

Interfacing monolith-based electrochromatography in microchips with inductively coupled plasma mass spectrometry for elemental speciation

H. Cheng, P. Li, J. Liu and Z. Xu, J. Anal. At. Spectrom., 2016, 31, 1869 DOI: 10.1039/C6JA00112B

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