Issue 3, 2015

Novel strategies for catalytic asymmetric synthesis of C1-chiral 1,2,3,4-tetrahydroisoquinolines and 3,4-dihydrotetrahydroisoquinolines

Abstract

1,2,3,4-Tetrahydroisoquinoline is one of the most important “privileged scaffolds” present in natural products. C1-chiral tetrahydroisoquinolines have exhibited a wide variety of bioactivities and found applications as chiral scaffolds in asymmetric catalysis. This paper summarizes novel catalytic stereoselective strategies that emerged in the last ten years for synthesis of 1,2,3,4-tetrahydroisoquinoline and 3,4-dihydroisoquinoline scaffolds, beyond the traditional Pictet–Spengler and related protocols, as well as their applications in the total synthesis of alkaloid natural products.

Graphical abstract: Novel strategies for catalytic asymmetric synthesis of C1-chiral 1,2,3,4-tetrahydroisoquinolines and 3,4-dihydrotetrahydroisoquinolines

Associated articles

Article information

Article type
Review Article
Submitted
08 nov 2014
Accepted
14 dec 2014
First published
16 dec 2014

Org. Chem. Front., 2015,2, 288-299

Author version available

Novel strategies for catalytic asymmetric synthesis of C1-chiral 1,2,3,4-tetrahydroisoquinolines and 3,4-dihydrotetrahydroisoquinolines

W. Liu, S. Liu, R. Jin, H. Guo and J. Zhao, Org. Chem. Front., 2015, 2, 288 DOI: 10.1039/C4QO00294F

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