Issue 1, 2015

Chromium-catalyzed transformations with Grignard reagents – new opportunities for cross-coupling reactions

Abstract

Beyond classic Nozaki–Hiyama–Kishi reactions, a low-cost and low-toxicity chromium(II) salt was recently shown to have the capability to catalyze the cross-couplings of C–X and C–H bonds with Grignard reagents. It is a remarkable progression and would point to a new direction for future development of chromium catalysis, as well as opening new opportunities for discovery of new cross-coupling reactions. This highlight focuses on these advances in chromium-catalyzed transformations using Grignard reagents.

Graphical abstract: Chromium-catalyzed transformations with Grignard reagents – new opportunities for cross-coupling reactions

Article information

Article type
Highlight
Submitted
22 okt 2014
Accepted
26 nov 2014
First published
27 nov 2014

Org. Chem. Front., 2015,2, 69-72

Author version available

Chromium-catalyzed transformations with Grignard reagents – new opportunities for cross-coupling reactions

X. Zeng and X. Cong, Org. Chem. Front., 2015, 2, 69 DOI: 10.1039/C4QO00272E

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