Issue 10, 2015

Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases

Abstract

Cucurbiturils (CB6 and CB7) were shown to inhibit the enzymatically catalyzed restriction of plasmids and linear DNA. This effect can be inverted by supramolecular masking of the macrocycles through competitive complexation with polyamines. These experiments provide supramolecular control of biocatalytic processes.

Graphical abstract: Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases

Supplementary files

Article information

Article type
Communication
Submitted
04 okt 2014
Accepted
24 dec 2014
First published
12 jan 2015
This article is Open Access
Creative Commons BY-NC license

Org. Biomol. Chem., 2015,13, 2866-2869

Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases

C. Parente Carvalho, A. Norouzy, V. Ribeiro, W. M. Nau and U. Pischel, Org. Biomol. Chem., 2015, 13, 2866 DOI: 10.1039/C4OB02122C

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