Issue 5, 2014

The highly enantioselective catalytic aza-Morita–Baylis–Hillman reaction

Abstract

The highly enantioselective aza-Morita–Baylis–Hillman (aza-MBH) reaction is one of the most important reactions for the synthesis of optically active α-methylene-β-amino carbonyl compounds. The use of chiral phosphines or amines as organocatalysts can be envisaged for this catalytic asymmetric reaction. This mini review focuses on the important developments with regard to asymmetric aza-MBH reactions catalyzed by chiral phosphines or amines or even organometallic complexes in recent decades and also on the perspectives that these new developments offer.

Graphical abstract: The highly enantioselective catalytic aza-Morita–Baylis–Hillman reaction

Supplementary files

Article information

Article type
Tutorial Account
Submitted
23 jan 2014
Accepted
07 mar 2014
First published
13 mar 2014

Org. Chem. Front., 2014,1, 587-595

The highly enantioselective catalytic aza-Morita–Baylis–Hillman reaction

F. Hu and M. Shi, Org. Chem. Front., 2014, 1, 587 DOI: 10.1039/C4QO00026A

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