Issue 4, 2014

Recent advances in C–H fluorination

Abstract

Incorporation of fluorine atom(s) into organic compounds is often desirable in the discovery of new pharmaceuticals, agrochemicals, and materials. However, development of transformations to incorporate fluorine is challenging because of its highly electronegative nature. Recent advances in C–H functionalization have allowed new approaches to C–F bonds. Herein we highlight progress in C–H fluorination, which is arguably the most efficient approach to incorporate fluorine since it obviates the need of pre-functionalization of organic compounds.

Graphical abstract: Recent advances in C–H fluorination

Article information

Article type
Highlight
Submitted
20 jan 2014
Accepted
05 feb 2014
First published
07 mar 2014

Org. Chem. Front., 2014,1, 434-438

Author version available

Recent advances in C–H fluorination

A. Lin, C. B. Huehls and J. Yang, Org. Chem. Front., 2014, 1, 434 DOI: 10.1039/C4QO00020J

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