Issue 2, 2014
From the journal:

Organic Chemistry Frontiers

Copper-mediated efficient three-component synthesis of 1,2,4-triazoles from amines and nitriles†‡

Jinqiang Kuang,a   Bo Chena  and  Shengming Ma*ab  

* Corresponding authors

a State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, P. R. China
E-mail: masm@sioc.ac.cn
Fax: (+86)-21-6260-9305

b Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry East, China Normal University, 3663 North Zhongshan Road, Shanghai 200062, P. R. China

Abstract

An efficient copper-mediated three-component reaction of one molecule of amine and two molecules of nitriles affording fully substituted 1,2,4-triazoles has been developed. A tandem double addition–oxidative cyclization mechanism has been proposed for the synthesis of 1,2,4-triazoles.

Graphical abstract: Copper-mediated efficient three-component synthesis of 1,2,4-triazoles from amines and nitriles

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4QO00007B
Article type
Research Article
Submitted
08 jan 2014
Accepted
15 jan 2014
First published
30 jan 2014

Org. Chem. Front., 2014,1, 186-189

Permissions

Request permissions

Copper-mediated efficient three-component synthesis of 1,2,4-triazoles from amines and nitriles

J. Kuang, B. Chen and S. Ma, Org. Chem. Front., 2014, 1, 186 DOI: 10.1039/C4QO00007B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements