Issue 2, 2014

Copper-mediated efficient three-component synthesis of 1,2,4-triazoles from amines and nitriles

Abstract

An efficient copper-mediated three-component reaction of one molecule of amine and two molecules of nitriles affording fully substituted 1,2,4-triazoles has been developed. A tandem double addition–oxidative cyclization mechanism has been proposed for the synthesis of 1,2,4-triazoles.

Graphical abstract: Copper-mediated efficient three-component synthesis of 1,2,4-triazoles from amines and nitriles

Supplementary files

Article information

Article type
Research Article
Submitted
08 jan 2014
Accepted
15 jan 2014
First published
30 jan 2014

Org. Chem. Front., 2014,1, 186-189

Copper-mediated efficient three-component synthesis of 1,2,4-triazoles from amines and nitriles

J. Kuang, B. Chen and S. Ma, Org. Chem. Front., 2014, 1, 186 DOI: 10.1039/C4QO00007B

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