Issue 85, 2014

SmI2–H2O-mediated 5-exo/6-exo lactone radical cyclisation cascades

Abstract

The SmI2H2O reagent system mediates challenging 5-exo/6-exo lactone radical cascade cyclisations that deliver carbo[5.4.0]bicyclic motifs in a diastereoselective, one-pot process that establish two new carbocyclic rings and four stereocentres.

Graphical abstract: SmI2–H2O-mediated 5-exo/6-exo lactone radical cyclisation cascades

Supplementary files

Article information

Article type
Communication
Submitted
14 jul 2014
Accepted
15 avg 2014
First published
15 avg 2014

Chem. Commun., 2014,50, 12863-12866

Author version available

SmI2–H2O-mediated 5-exo/6-exo lactone radical cyclisation cascades

I. Yalavac, S. E. Lyons, M. R. Webb and D. J. Procter, Chem. Commun., 2014, 50, 12863 DOI: 10.1039/C4CC05404K

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