Issue 42, 2012
From the journal:

Chemical Communications

An organocatalytic Michael-aldol cascade: formal [3+2] annulation to construct enantioenriched spirocyclic oxindole derivatives†‡

Shu-Wen Duan,a   Yang Li,a   Yi-Yin Liu,a   You-Quan Zou,a   De-Qing Shia  and  Wen-Jing Xiao*a  

* Corresponding authors

a Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China
E-mail: wxiao@mail.ccnu.edu.cn
Fax: +86 27 67862041
Tel: +86 27 67862041

Abstract

An efficient organocatalytic Michael-aldol cascade reaction for the asymmetric synthesis of spirocyclic oxindole derivatives fused with tetrahydrothiophenes has been developed through a formal [3+2] annulation strategy.

Graphical abstract: An organocatalytic Michael-aldol cascade: formal [3+2] annulation to construct enantioenriched spirocyclic oxindole derivatives

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Article information

DOI
https://doi.org/10.1039/C2CC30931A
Article type
Communication
Submitted
09 Feb 2012
Accepted
05 Mar 2012
First published
05 Mar 2012

Chem. Commun., 2012,48, 5160-5162

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An organocatalytic Michael-aldol cascade: formal [3+2] annulation to construct enantioenriched spirocyclic oxindole derivatives

S. Duan, Y. Li, Y. Liu, Y. Zou, D. Shi and W. Xiao, Chem. Commun., 2012, 48, 5160 DOI: 10.1039/C2CC30931A

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