Issue 36, 2011
From the journal:

Chemical Communications

A fluoro analogue of UDP-α-d-glucuronic acid is an inhibitor of UDP-α-d-apiose/UDP-α-d-xylose synthase†‡

Sei-hyun Choi,a   Mark W. Ruszczycky,b   Hua Zhangb  and  Hung-wen Liu*ab  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of Texas at Austin, Texas 78712, Austin, USA
E-mail: h.w.liu@mail.utexas.edu
Tel: +1 512-232-7811

b Medicinal Chemistry Division, College of Pharmacy, University of Texas at Austin, Texas 78712, Austin, USA

Abstract

UDP-2F-glucuronic acid was synthesized and analyzed as a mechanistic probe to investigate the ring contraction step catalyzed by UDP-D-apiose/UDP-D-xylose synthase (AXS).

Graphical abstract: A fluoro analogue of UDP-α-d-glucuronic acid is an inhibitor of UDP-α-d-apiose/UDP-α-d-xylose synthase

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Article information

DOI
https://doi.org/10.1039/C1CC13140K
Article type
Communication
Submitted
27 maj 2011
Accepted
20 jul 2011
First published
09 avg 2011

Chem. Commun., 2011,47, 10130-10132

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A fluoro analogue of UDP-α-D-glucuronic acid is an inhibitor of UDP-α-D-apiose/UDP-α-D-xylose synthase

S. Choi, M. W. Ruszczycky, H. Zhang and H. Liu, Chem. Commun., 2011, 47, 10130 DOI: 10.1039/C1CC13140K

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