Issue 31, 2011
From the journal:

Chemical Communications

Multiplexed binding determination of seven glycoconjugates for Pseudomonas aeruginosa Lectin I (PA-IL) using a DNA-based carbohydrate microarray†‡

Yann Chevolot,*a   Jing Zhang,a   Albert Meyer,b   Alice Goudot,a   Sonia Rouanet,b   Sébastien Vidal,c   Gwladys Pourceau,b   Jean-Pierre Cloarec,a   Jean-Pierre Praly,c   Eliane Souteyrand,a   Jean-Jacques Vasseurb  and  François Morvan*b  

* Corresponding authors

a INL UMR5270 CNRS Ecole Centrale de Lyon, 36 avenue G. de Collongue, 69134 Ecully Cedex, France
E-mail: yann.chevolot@ec-lyon.fr
Fax: (+33) 472 18 6250
Tel: (+33) 472 18 6240

b IBMM UMR 5247 CNRS UM1 UM2, Université de Montpellier 2 Place Eugène Bataillon, F-34095 Montpellier Cedex 5, France
E-mail: morvan@univ-montp2.fr
Fax: (+33) 467 042 029
Tel: (+33) 467 144 961

c ICBMS UMR 5246, Laboratoire de Chimie Organique 2 Glycochimie, CNRS Université Lyon 1, 43 Bd du 11 Novembre 1918, F-69622 Villeurbanne, France

Abstract

The binding of seven multivalent glycoconjugates displaying linear or antenna-like structures and different electronic environments were evaluated towards PA-IL on a DNA-based carbohydrate microarray. The affinity can be modulated by the charge and the topology of the galactosylated derivatives.

Graphical abstract: Multiplexed binding determination of seven glycoconjugates for Pseudomonas aeruginosa Lectin I (PA-IL) using a DNA-based carbohydrate microarray

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Article information

DOI
https://doi.org/10.1039/C1CC12428E
Article type
Communication
Submitted
26 apr 2011
Accepted
20 jun 2011
First published
11 jul 2011

Chem. Commun., 2011,47, 8826-8828

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Multiplexed binding determination of seven glycoconjugates for Pseudomonas aeruginosa Lectin I (PA-IL) using a DNA-based carbohydrate microarray

Y. Chevolot, J. Zhang, A. Meyer, A. Goudot, S. Rouanet, S. Vidal, G. Pourceau, J. Cloarec, J. Praly, E. Souteyrand, J. Vasseur and F. Morvan, Chem. Commun., 2011, 47, 8826 DOI: 10.1039/C1CC12428E

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