Issue 44, 2020

Diverse synthesis of pyrano[3,2-c]coumarins: a brief update

Abstract

Functionalized pyranocoumarins are an important class of oxygen-containing heterocyclic compounds. Fused coumarin systems, in particular pyranocoumarins, are abundant in nature and constitute building blocks for many natural products found across the plant kingdom. Pyranocoumarin derivatives have been found to possess antifungal, insecticidal, anticancer, anti-HIV, anti-inflammatory, antioxidant, and antibacterial activities. Synthesis of this moiety from easily available chemicals is desirable due to its tremendous use in various branches of chemistry. Owing to the broad spectrum of biological properties and natural occurrence, pyrano[3,2-c]coumarins have become attractive synthetic targets from the point of view of medicinal chemistry. This short review discusses the synthesis of this scaffold using different strategies including mechanistic illustrations.

Graphical abstract: Diverse synthesis of pyrano[3,2-c]coumarins: a brief update

Article information

Article type
Perspective
Submitted
30 jul 2020
Accepted
23 sep 2020
First published
24 sep 2020

New J. Chem., 2020,44, 18980-18993

Diverse synthesis of pyrano[3,2-c]coumarins: a brief update

A. Mukherjee, S. Mahato, G. V. Zyryanov, A. Majee and S. Santra, New J. Chem., 2020, 44, 18980 DOI: 10.1039/D0NJ03846F

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