Issue 6, 2018

Recent advances in the intramolecular Mannich reaction in natural products total synthesis

Abstract

The Mannich reaction has been widely used to effectively construct C–N and C–C bonds in organic synthesis. This review focuses on selected applications of the intramolecular Mannich reaction as a key step in the total synthesis of natural products (2000–2017). The organization of the synthetic applications is based on the structure of newly-formed skeletons using the intramolecular Mannich reaction, which include aza-fused rings and aza-bridged rings.

Graphical abstract: Recent advances in the intramolecular Mannich reaction in natural products total synthesis

Article information

Article type
Review Article
Submitted
01 dec 2017
Accepted
04 jan 2018
First published
09 jan 2018

Org. Chem. Front., 2018,5, 1049-1066

Recent advances in the intramolecular Mannich reaction in natural products total synthesis

Y. Shi, Q. Wang and S. Gao, Org. Chem. Front., 2018, 5, 1049 DOI: 10.1039/C7QO01079F

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