Issue 31, 2016

Small molecule-mediated duplex formation of nucleic acids with ‘incompatible’ backbones

Abstract

Proflavine, a known intercalator of DNA and RNA, promotes duplex formation by nucleic acids with natural and non-natural backbones that otherwise form duplexes with low thermal stability, and even some that show no sign of duplex formation in the absence of proflavine. These findings demonstrate the potential for intercalators to be used as cofactors for the assembly of rationally designed nucleic acid structures, and could provide fundamental insights regarding intercalation of natural nucleic acid duplexes.

Graphical abstract: Small molecule-mediated duplex formation of nucleic acids with ‘incompatible’ backbones

  • This article is part of the themed collection: Foldamers

Supplementary files

Article information

Article type
Communication
Submitted
26 jan 2016
Accepted
09 mar 2016
First published
09 mar 2016

Chem. Commun., 2016,52, 5436-5439

Small molecule-mediated duplex formation of nucleic acids with ‘incompatible’ backbones

B. J. Cafferty, C. Musetti, K. Kim, E. D. Horowitz, R. Krishnamurthy and N. V. Hud, Chem. Commun., 2016, 52, 5436 DOI: 10.1039/C6CC00779A

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