Issue 58, 2016

Synthesis of functionalized amino epoxides by a three-component coupling involving aziridines, arynes and aldehydes

Abstract

A transition-metal-free three-component coupling involving N-substituted aziridines, arynes and aldehydes resulting in the formation of trisubstituted N-aryl α-amino epoxides has been demonstrated. The reaction likely proceeds via the highly strained cyclic nitrogen ylide intermediates generated from aziridines and arynes.

Graphical abstract: Synthesis of functionalized amino epoxides by a three-component coupling involving aziridines, arynes and aldehydes

Supplementary files

Article information

Article type
Communication
Submitted
04 jan 2016
Accepted
19 jan 2016
First published
20 jan 2016

Chem. Commun., 2016,52, 9044-9047

Synthesis of functionalized amino epoxides by a three-component coupling involving aziridines, arynes and aldehydes

T. Roy, M. Thangaraj, R. G. Gonnade and A. T. Biju, Chem. Commun., 2016, 52, 9044 DOI: 10.1039/C6CC00057F

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