Issue 7, 2015

A block copolymer of zwitterionic polyphosphoester and polylactic acid for drug delivery

Abstract

Polymeric nanoparticles have been widely used as nano-drug delivery systems in preclinical and clinical trials for cancer therapy, and these systems usually need to be sterically stabilized by poly(ethylene glycol) (PEG) to maintain stability and avoid rapid clearance by the immune system. Recently, zwitterionic materials have been demonstrated to be potential alternatives to the classic PEG. Herein, we developed two drug delivery systems stabilized by zwitterionic polyphosphoesters. These nanoparticles showed favourable stability and anti-protein absorption ability in vitro. Meanwhile, as drug carriers, these zwitterionic polyphosphoester-stabilized nanoparticles significantly prolonged drug circulation half-lives and increased drug accumulation in tumors, which was comparable to PEG-stabilized nanoparticles. Systemic delivery of doxorubicin (DOX) by zwitterionic polyphosphoester-stabilized nanoparticles significantly inhibited tumor growth in a MDA-MB-231 tumor model, suggesting the potential of zwitterionic polyphosphoester-based nanoparticles in anticancer drug delivery.

Graphical abstract: A block copolymer of zwitterionic polyphosphoester and polylactic acid for drug delivery

Supplementary files

Article information

Article type
Paper
Submitted
11 dec 2014
Accepted
06 feb 2015
First published
04 mar 2015

Biomater. Sci., 2015,3, 1105-1113

A block copolymer of zwitterionic polyphosphoester and polylactic acid for drug delivery

R. Sun, X. Du, C. Sun, S. Shen, Y. Liu, X. Yang, Y. Bao, Y. Zhu and J. Wang, Biomater. Sci., 2015, 3, 1105 DOI: 10.1039/C4BM00430B

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