Zhuang Mao Png, Jaime R. Cabrera-Pardo, Jorge Peiró Cadahía and Matthew J. Gaunt
Chem. Sci., 2018,9, 7628-7633
DOI:
10.1039/C8SC02855A,
Edge Article
A palladium(II)-catalysed C(sp3)–H carbonylation of free(NH) secondary aliphatic amines to 2-pyrrolidinones is described. A correlation between the nature of the carboxylate ligand and the diastereoselectivity and yield of the process was observed. As such, under these optimal conditions a range of aliphatic amines were converted to the corresponding trans-4,5-disubstituted 2-pyrrolidines with good d.r. and yield.